Lonza has a strong reputation for expertise in many areas of drug discovery, from the earliest research through to biopharmaceutical production. Our presence in many pharmaceutical product and service markets helps us to understand the limitations of existing technologies and guides our efforts to find and develop better solutions for our customers.
We recognize the importance of consistent tools in drug discovery and strive to standardize highly relevant, but variable, products like primary cells. Our dedicated drug discovery team helps you to focus on critical areas of product and service development.
Odyssey Thera Compound Profiling Services
Using cutting edge Protein-fragment Complementation Assay technology from Odyssey Thera, Lonza is able to offer profiling services that can shape and influence critical decisions about drug candidates. This unique cellwide analysis platform broadly addresses target classes, signaling pathways and cellular processes, classifying drugs by comparison to an extensive compound database defining MOA and predicting safety threats.
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Clonetics® Primary Sensors
- Primary cells containing biosensors of key signalling pathways
- Measure endogenous receptors in primary cells with the convenience associated with recombinant cell lines
- Cells ready to thaw and use
- Luminescence signals for maximum sensitivity
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Cor.At® Mouse ES Cell Derived Cardiomyocytes
Our Cor.At® cardiomyocytes express all relevant ion channels and have been validated in a range of safety applications, including automated patch-clamp and non-arrhythmic cardiotoxicity assessment.
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Cells on Demand™ Cell Culture and Transfection Services
The advancement of assay technologies has enabled the use of live cells in over 50% of high throughput screenings. As a result, cell provision has become a limiting factor for both throughput and quality of cell based screening. Lonza Research Solutions has decades of experience in providing high quality cell products and services, including bulk production of primary cells and cell lines, both unmodified and transfected.
Conditionally Immortalized Cells
By combining the proliferation driving power of ts LT and telomerase to manage cellular senescence, one achieves conditional immortalization. Conditional immortalization allows, at a permissive temperature, production of large, uniform cell populations. By increasing the culture temperature, the cells stop dividing. One then converts to a differentiation medium, so that the cells can express normal differentiated function and phenotype once again.
Now drug discovery researchers have access to an unlimited supply of differentiated cells of the same genotype that can be used as models in drug discovery programs for functional cell-based assays and long-term gene expression studies.
Naïve cells
Lonza Research Solutions is continually looking for new sources of cells, especially those harbouring disease. A broad range of diseased cell types are available, even those considered naïve, or cells from patients who have not been medicated. Such a supply of diseased cells allows researchers the chance to pair disease state cells with Clonetics® Normal Human Cells.
To request more information about the possibilities:
Email: cellsondemand@lonza.com
Primary Hepatocytes
Lonza hepatocytes are well characterised and have been shown to perform well in metabolism and liver toxicity assays.
- Readily available, well characterized and exhibit minimal variablity (within a single lot)
- Donor information available with each shipment
- Additional characterization available on selected lots
Luminescent Bioassays
Convenient assays for cell function are useful tools in drug discovery. We recognize the need for assay robustness even with highly relevant primary cells and our cell based assays are designed with this in mind.
- Specific assays for cell viability (ViaLight®) and cell death (ToxiLight®)
- Luminescence signals for maximum sensitivity and minimal compound interference
- Wide dynamic range and scalability from 96 to 1536 formats
- Simple (no-shake) protocols for easy automation
High Throughput Screening Assays
- Luminescence assays for PDE and Cyclase activity
- Rapid, easy and reproducible measurement of cAMP and PPi
- Scalable from 96 to 1536 wells
